For instance, miR-21 promotes CD4+ T cell glycolysis through the PTEN/PI3K/AKT pathway, which increases the cell cycle, promotes CD4+ T cell polarization toward the Th2 phenotype, and releases the fibrogenic cytokine IL-13, which is involved in arsenite-induced hepatic fibrosis [110] (Fig. 5A). Here, CD4 is linked to Hepatic fibrosis.