The study underscores the pivotal role of Ccl19+ FRCs in enhancing T-cell effector functions within the TME in NSCLC and suggests that CD8+ T cells achieve full effector potential through their interactions with CCL19-expressing FRCs in the TME after initial activation and proliferation in draining lymph nodes.1 This evidence concerns the gene CCL19 and non-small cell lung carcinoma.