Indeed, we observed a significant positive correlation of TGFB1 with MMP11 and a significant negative correlation with MMP26 expression in several PCa gene expression datasets, including primary PRAD TCGA [50] (n = 493) cohort, MSKCC primary [52] (n = 131), Broad/Cornell [55] (n = 31), SMMU [54] (n = 65) and DKFZ [53] (n = 118), but not in the non-cancerous tissues (MSKCC cohort, n = 29) (Fig. 4B). This evidence concerns the gene MMP26 and posterior cortical atrophy.