First, we analysed samples from patients with oligometastatic PCa treated with local ablative radiotherapy (n = 31) (Table 1) and healthy donors (n = 5) and found significantly higher concentrations of MMP11 in the samples from PCa patients, whereas TGF-β1 has shown a similar but not significant trend (Fig. 6B). This evidence concerns the gene TGFB1 and posterior cortical atrophy.