Previous studies on other types of tumors, including mesothelioma as well as breast and pancreatic cancer, revealed that ATRA and RARA act at multiple levels of the TGF-β1 signaling and regulate expression of the receptors, ligands, and signal transducers suggesting crosstalk of the TGF-β1 and retinoid signaling [28–31]. Here, TGFB1 is linked to pancreatic neoplasm.