In the present study, we firstly comprehensively examined the direct regulatory effect by CILP‐1 on the matrix metabolism of NP cells, including pro‐anabolic and pro‐catabolic cytokines and proteases, to validate whether up‐regulated CILP‐1 acts as a direct contributor to IDD by promoting matrix degradation. This evidence concerns the gene CILP and intervertebral disk degenerative disorder.