Also, the ATF3 levels in the xenograft tumors developed from the FADS1-KD cells are not significantly different from that of the control tumors, though an apparent trend can be observed (5 out of 7 FADS1-KD tumors demonstrated an elevated level of ATF3), which may be largely due to the potential sex-specific differences, tumor-specific extent of ER stress, and the small sample size. This evidence concerns the gene FADS1 and neoplasm.