To this end, a report that amlodipine (AMD), a calcium channel blocker (CCB) and a commonly used hypertension drug, downregulated the release of sEV from tumor cells (19)prompted us to advance the hypothesis that AMD blocks TEX release by human cancer cells in vitro and murine cancer cells in vivo, thereby suppressing tumor growth and promoting recovery of anti-tumor immunity. Here, TEX46 is linked to neoplasm.