For this, weighted gene co-expression network analysis (WGCNA) of malignant HNSCC cells within the external scRNA-seq dataset GSE103322 (n = 2,176 [5]) served to identify module “brown” as most strongly associated with EGF-EGFR/MAPK signaling activity and EMT. This evidence concerns the gene EGF and head and neck squamous cell carcinoma.