AREG, COL17A1, EREG, FOSL1, ITGA3, ITGB4, LAMA3, LAMC2, MT2A, PHLDA1, and PLEK2 were upregulated in R/M-HNSCC-patients with long PFS, (AUC (ROC) 0.681–0.879) (Suppl. Here, PLEK2 is linked to head and neck squamous cell carcinoma.