Therefore, we used publicly available spatial transcriptomic (ST) data to interrogate sub-localizations of fDEGs in tumor core (TC), and leading edge (LE) of oral SCC (external dataset GSE208253 [18]), as exemplified for ITGB4, LAMA3, LAMB3, and LAMC2 (Fig. 8C). This evidence concerns the gene LAMB3 and neoplasm.