One symptom that can be associated with Singleton-Merten syndrome, is the development of psoriatic skin lesions [58] and a RIG-I gain-of-function mouse that harbours a Singleton-Merten syndrome-associated mutation, develops psoriasis-like lesions on the tail and back, suggesting that in this model areas of mechanical stress might be more prone to the development of lesions [59]. Here, RIGI is linked to psoriasis.