Though extracellular stimulation of keratinocytes with high concentrations of the double-stranded RNA (dsRNA) synthetic analogue Poly(I:C) was shown to induce IL-36γ release from keratinocytes [23], genome-wide association studies have shown a link between the genes encoding the dsRNA intracellular sensors retinoic acid-inducible gene I (RIG-I) and melanoma differentiation-associated protein 5 (MDA5) with an increased risk of psoriasis vulgaris [24–26]. This evidence concerns the gene RIGI and psoriasis vulgaris.