Importantly, ZHX2 or p65 overexpression significantly rescued ccRCC cell growth and NF-κB target gene expression after XMU-MP-1 treatment (Fig. 6, A–F), lending further support that YAP inhibits ccRCC cell growth by opposing the cooperativity between p65 and ZHX2. Here, ZHX2 is linked to nonpapillary renal cell carcinoma.