Intriguingly, we found that XMU-MP-1 also inhibited cancer cell growth of multiple VHL mutant ccRCC cell lines including 786-O cells in 2D cultures where HIF-2α pathway activity was dispensable for their growth (Fig.1, A–C) (30, 34, 35), raising the possibility that XMU-MP-1 could inhibit ccRCC cell growth through a mechanism(s) other than blocking HIF-2α pathway activity. The gene discussed is EPAS1; the disease is nonpapillary renal cell carcinoma.