Importantly, ZHX2 or p65 overexpression significantly rescued ccRCC cell growth and NF-κB target gene expression after XMU-MP-1 treatment (Fig. 6, A–F), lending further support that YAP inhibits ccRCC cell growth by opposing the cooperativity between p65 and ZHX2. This evidence concerns the gene YAP1 and nonpapillary renal cell carcinoma.