These were fibroblast growth factor 5 (Fgf5) expressed in melanoma, Mushashi 1 (Msi1) an RNA binding protein that regulates apoptosis, differentiation and proliferation; and lymphoid enhancer factor (Lef1), the key transcription factor in Wnt/β-catenin signaling involved in development, regeneration and cancer, and highly downregulated in Acomys in this study (Fig. 2H). This evidence concerns the gene FGF5 and cancer.