NFKB1 and colorectal carcinoma: Persistent chronic inflammation leads to CRC by facilitating the accumulation of DNA damage and mutations, activating the immune system for abnormal cell proliferation and carcinogenesis, inducing aberrant DNA methylation and histone modifications, and triggering dysregulated activation of key signaling pathways, such as nuclear factor kappa‐B (NF‐κB) and JAK/STAT, to promote cell proliferation and inhibit apoptosis [7].