Studies found that altered flora in patients with neonatal necrotizing small bowel colitis led to significant intestinal inflammation, resulting in increased expression of IL‐1, IL‐2, IL‐4, IL‐6, IL‐8, IL‐10, TNF‐α, IFN‐γ, and IL‐17 in samples [54]. The gene discussed is CXCL8; the disease is inflammatory response.