An early pharmacological research has demonstrated that SYD effectively alleviates chemical colitis by triggering GPX4, preventing iron ptosis in epithelial cells, and further restoring barrier function, and furthermore determined that Wogonoside, Wogonin, Palmatine, Paeoniflorin, and Liquirin are the main medicinal substances responsible for SYD's anti‐colitis actions [40]. Here, GPX4 is linked to colitis.