SYD has been found to reduce key inflammatory markers such as IL‐1, IL‐6, and TNF‐α, resulting in decreased tumor‐associated macrophage (TAM) infiltration and NF‐κB activation, thereby inhibiting Snail‐induced epithelial–mesenchymal transition (EMT) and subsequently CRC progression [33]. This evidence concerns the gene NFKB1 and colorectal carcinoma.