APP and Alzheimer disease: In 3xTG‐AD (carrying a mutation in three genes: APP K670_M67, PSEN1 M146V, and MAPT P301L), PDAPP‐J20 (PDGFB‐APPSwInd with a mutation in the APP gene) and APP/PS1dE9 (expressing a chimeric mouse/human amyloid precursor protein [Mo/HuAPP695swe] and a mutant human presenilin 1 [PS1‐dE9]) the astroglial volume, surface area, and complexity were found to be reduced overall (Endo et al. 2022; Olabarria et al. 2010; Yeh et al. 2011; Kulijewicz‐Nawrot et al. 2012; Beauquis et al. 2013; Rodriguez‐Arellano et al. 2016).