Recent transcriptomic analysis in PSP patients (Sharma et al. 2021; Briel et al. 2022), iPSC‐derived astrocytic cultures (Ezerskiy et al. 2022) and tau transgenic mice (Dejanovic et al. 2018; Litvinchuk et al. 2018; Jiwaji et al. 2022) have revealed astrocyte profiles associated with both deleterious and adaptive‐protective signals, compatible with the co‐existence of astrocytic sub‐types in tauopathies. Here, MAPT is linked to tauopathy.