Taking advantage of this model, herein we sought to determine if RBM20 modulates titin isoform switching in smooth muscle; if titin‐based changes in VSMC tone impact overall arterial stiffness; and whether modulation of arterial stiffness through the RBM20‐titin axis is beneficial for hypertension‐induced cardiac hypertrophy and remodeling. Here, RBM20 is linked to cardiac hypertrophy.