AGTR1 and cardiovascular disorder: Although natriuretic peptide release by atria in response to stretch is primarily mediated by signaling through the heterotrimeric G protein ⍺ subunit, G⍺o (35,36), it is also robustly enhanced in response to activation of G⍺q-coupled receptors such as activation of AT1R by elevated circulating angiotensin-II in cardiovascular disease (1,2,37,38).