A comparison of EVs from CTC-MCC-41 and CTC-MCC-41.5G cells (obtained before and after therapy failure, respectively) revealed a significantly greater presence of proteins associated with stemness (CD44 and EpCAM) [7, 20] and proteins implicated in prognosis and cancer metastasis (ITGB1, CAB39, H2AFY, VIL1, CCT8, and ADAM10) [17, 18]. Here, CD44 is linked to cancer.