EVs derived from CTC-MCC-41.4 and CTC-MCC-41.5G cells exhibited distinct distribution patterns, possibly due to their “exosomal” profile, according to Vesiclepedia [13], and their greater abundance of surface proteins associated with metastasis (ITGB1, CD44, and EpCAM). The gene discussed is ITGB1; the disease is Merkel cell skin cancer.