Model 1 and Model 4: unadjusted; Model 2 and Model 5: adjusted for gender, age smoking, drinking, and BMI; Model 3 and Model 6: adjusted for gender, age, smoking, drinking, BMI, hypertension, arrhythmia, CHD, cerebral infarction, hyperuricemia, NYHA classification, drugs for the treatment of DM, NTHF, Statins, DDM, HbA1c, BNP, and EF. The gene discussed is NPPB; the disease is brain infarction.