Model 1: unadjusted; Model 2: adjusted for gender,age smoking, drinking, and BMI; Model 3: adjusted for gender, age, smoking, drinking, BMI, hypertension, arrhythmia, CHD, cerebral infarction, hyperuricemia, DDM, NTHF, hypoglycemic drugs, lipid-lowering drugs, NYHA classification, HbA1c, BNP, and EF. The gene discussed is NPPB; the disease is Hypertension.