NAT10 and neoplasm: Transwell assays showed that NAT10 KD using siRNA or shRNA could significantly attenuate tumor migration and invasion in PANC-1 (Fig. 2D and Fig. S2C-D) and MIA PaCa-2 (Fig. 2E and Fig. S2E-F) cells, indicating that NAT10 promotes PDAC migration and invasion in vitro.