The observed inverse correlation between DNA methylation and CCR1 expression in macrophages, implies that DNA hypomethylation adds an additional layer of regulation to CCR1 induction and macrophage recruitment, as it has been previously described in the context of COVID-19 (Chua et al, 2020; Stikker et al, 2022; Trump et al, 2021). The gene discussed is CCR1; the disease is COVID-19.