MIA3 and osteochondrodysplasia: This fetus was found to harbor a homozygous frameshift variant (c.2770_2773del, p.Leu924SerfsTer2) which affected the luminal portion of TANGO1 and mimicked a complete loss-of-function situation, similar to that observed in MIA3−/− pups, which displayed early neonatal lethality associated with osteochondrodysplasia, lack of bone mineralization, dwarfism, and defective collagen secretion [17].