KL and obesity due to melanocortin 4 receptor deficiency: According to current knowledge, changes in the Klotho gene may be linked to liver damage in kids with non-alcoholic fatty liver disease (NAFLD) [199, 200], and by controlling the breakdown of energy and adversely influencing the Wnt/b-catenin signaling pathway, Klotho can stop the advancement of liver cancer and decrease obesity. Furthermore, compared to controls, one study indicated that children with alcoholic cirrhosis had considerably greater Klotho levels [201].