SERPINF1 and retinitis pigmentosa 1: These peptides show potential to overcome the challenging genetic heterogeneity characterizing RP as demonstrated in distinctive models: the rd10 containing an alteration in the visual transduction enzyme PDE6, and the RhoP23H/+ characterized by an alteration in the light receptor rhodopsin protein, modelling different types of human RP; and the rd10/Serpinf1-/, a more aggressive variant of the rd10 model lacking PEDF; as well as human hiPSCs-derived retinal organoids undergoing oxidative stress, a feature of RP12,16,18.