In the course of these studies two cell surface proteins residing in adherens junctions N-cadherin (NCAD) and ADAM15, a disintegrin metalloproteinase strongly expressed in inflamed synovial membranes of RA patients3, proved to be crucial in a signaling pathway that involves the long noncoding RNA (lncRNA) H19. This evidence concerns the gene ADAM15 and rheumatoid arthritis.