To clarify whether FDX1 affects ALCAM expression by regulating FMR1, we first detected the expression of the ALCAM protein in 6 ccRCC lines (RCC4, 769-P, 786-O, OSRC2, Caki-1, and A498) and compared it with its expression in the HK2 cell line. The gene discussed is FMR1; the disease is nonpapillary renal cell carcinoma.