Studies have shown that pancreatic ductal adenocarcinoma is one of the most immunosuppressive tumor types, and the increased expression of CRIP1 activates the CRIP1/NF-κB/CXCL axis to drive the migration and recruitment of MDSC and the infiltration of low CD8+ T-cells to form an immunosuppressive microenvironment [55]. The gene discussed is CD8A; the disease is neoplasm.