In contrast, DNMT3A showed a protective effect against IBD (OR = 0.47, 95%CI: 0.37–0.61, PPH4 = 0.93) and UC (OR = 0.53, 95%CI: 0.39–0.72, PPH4 = 0.93). The gene discussed is DNMT3A; the disease is inflammatory bowel disease.