By contrast, the gain-of-function mutation of NSD1 and formation of the NUP98-NSD1 fusion due to its in-frame fusion to NUP98, a factor carrying capabilities for condensation (57, 58) and coactivator recruitment (59, 60), points to an oncogenic role of NSD1 in driving aberrant expression of HOX genes in patients with acute myeloid leukemia (13, 41). Here, NSD1 is linked to acute myeloid leukemia.