In various normal and diseased settings such as mouse embryonic stem cells (mESCs) and acute myeloid leukemia, the NSD1-deposited H3K36me2 was shown to antagonize and restrict the spreading of polycomb repressive complex 2 (PRC2)-mediated H3K27me3 (13, 14, 15, 16). Here, NSD1 is linked to acute myeloid leukemia.