For instance, inactivation and frameshift mutations of NSD1 are frequent in patients with head and neck squamous cell carcinoma, which were reported to manifest an immune-cold tumor microenvironment partly due to the elevated H3K27me3 levels at key T cell-recruiting chemokines, CXCL9 and CXCL10 (55, 56). Here, CXCL9 is linked to neoplasm.