Noncoding variants located near exon-intronic junctions can influence the specific transcripts expressed for a gene through alternative or aberrant splicing, potentially leading to dysfunctional levels of the appropriate transcript or the production of an inappropriate splice variant, as seen with MYBPC3 variants linked to hypertrophic cardiomyopathy (Lopes et al., 2020). This evidence concerns the gene MYBPC3 and hypertrophic cardiomyopathy.