,77, 78, 79, 80, 81, 82, 83 In SATup DEGs, we found developmental, and obesity linked genes such as the well described HOXC cluster (HOXC4, HOXC5, HOXC6, HOXC8, HOX9, and HOXC10), TBX family (TBX5, TBX15, and TBX18), and IRX family (IRX1, IRX2, IRX3, and IRX5), highlighting their important role in adipose tissue biology and obesity pathogenesis. The gene discussed is HOXC5; the disease is obesity due to melanocortin 4 receptor deficiency.