OVATup DEGs included the kallikrein-related peptidases (KLKs) family (KLK5, KLK7,KLK10, and KLK11), the Keratin (KRT) family (KRT5, KRT7, KRT8, KRT18, and KRT19), and several other obesity associated genes that were previously reported in other studies (including ALOX15, UPK1B, GATA5, LRRN4, ANXA8, ANXA8L1, ISL1, MUC16, CKMT1A, CKMT1B, CDH3, CDH1, and CLDN1).8 The gene discussed is KLK7; the disease is obesity due to melanocortin 4 receptor deficiency.