,77, 78, 79, 80, 81, 82, 83 In SATup DEGs, we found developmental, and obesity linked genes such as the well described HOXC cluster (HOXC4, HOXC5, HOXC6, HOXC8, HOX9, and HOXC10), TBX family (TBX5, TBX15, and TBX18), and IRX family (IRX1, IRX2, IRX3, and IRX5), highlighting their important role in adipose tissue biology and obesity pathogenesis. Here, IRX5 is linked to obesity due to melanocortin 4 receptor deficiency.