This set includes genes that are involved in lipid response and were previously linked to obesity such as HAND2, HSD11B2, TNNT1, LRAT, and TMEM108. 8,101,102 Collectively, our data shows that depot specific expressed genes either regulated by differentially accessible super enhancers in SAT or promoters in OVAT, correlate with clinical variables important for anthropometric variables as well as to insulin, glucose, and lipid metabolism. The gene discussed is TMEM108; the disease is obesity due to melanocortin 4 receptor deficiency.