The increased production of SAM, the universal methyl donor, and 2-HG, a demethylase inhibitor (the involvement of 2-HG in demethylation and its impact on creating a highly plastic chromatin landscape has been demonstrated in BC) (33), leads to epigenetic, i.e., H3K4 trimethylation, fostered phenotypic plasticity. Here, MBD2 is linked to breast cancer.