Pathways that related to neural development were also overrepresented in breast microstructures upon OA, e.g., signaling by NTRKS (neurotrophic tyrosine receptor kinase) and nerve growth factor (NGF) stimulated transcription that have been associated with ERneg BC (35), stem cell self-renewal, and plasticity (36); MK signaling, which is involved in neurogenesis and cancer progression (24); and synthesis of neurotransmitters, which can be produced by nonneuronal cells including BC cells (37). The gene discussed is NGF; the disease is breast cancer.