The pleiotropic roles of ZFHX3 further extend in non-brain tissues with its recently described crucial involvement in angiogenesis for tumour development (Fu et al., 2020), cardiac function (Jameson et al., 2023), and spinocerebellar ataxia (Figueroa et al., 2024; Wallenius et al., 2024). Here, ZFHX3 is linked to cerebellar ataxia.