Of note, the concentration of AMD in ourexperimental system was 25 μM, which is lower than the therapeuticdose described in some preclinical studies.33,34 The consistent therapeutic effect observed across these treatmentssuggests that BTZ is an effective treatment in vitro, and that liposomes, whether conjugated or not, do not interferewith its apoptotic potential. This evidence concerns the gene CASC3 and age-related macular degeneration.