In this retrospective cohort study, utilising primary care data from the Clinical Practice Research Datalink (CPRD) Aurum database linked to Hospital Episode Statistics (HES) and Office for National Statistics (ONS) death registrations, we assessed male patients aged 40 and above diagnosed with PC and prescribed 1-, 3-, or 6-monthly LHRH agonist injections between January 2007 and December 2019. This evidence concerns the gene GNRH1 and pachyonychia congenita.