BACE1 and Alzheimer disease: Amyloid deposits compromise artery wall integrity, increasing the risk of rupture and hemorrhage, perhaps leading to strokes or other serious neurological consequences [10].Targeting BACE1 to reduce Aβ levels is a viable technique to address the underlying mechanisms of Alzheimer’s disease and amyloid cerebrovascular diseases, potentially reducing the risk of related cognitive decline and cerebrovascular accidents [6,11,12].