Senescence‐associated beta‐galactosidase (SA‐β‐gal) staining assay of 12Z cells further confirmed that rhChem157S promoted the cell aging (Figure 4F), indicating that over‐produced chemerin underpins the inflammaging of uterine endometrium during obesity. This evidence concerns the gene RARRES2 and obesity due to melanocortin 4 receptor deficiency.