CTLA4 and type 1 diabetes mellitus: In the present study, CTLA-4 A/A (frequencies were 125, 118 in patient and control groups, respectively), A/G (frequencies were 56, 57 in patient and control samples respectively) and G/G (frequencies were 19, 25 in patient and control groups, respectively) showed no significant correlation with T1D, same results were also observed in Jordanian population [9].