Basal forebrain atrophy has been linked to amyloid and Lewy-body pathology rather than LATE.15 Furthermore, the basal forebrain does not appear particularly susceptible to the TDP-43 pathology observed in frontotemporal lobar degeneration,16 and total basal forebrain volumes measured using MRI did not differ between patients with pure-AD and pure LATE neuropathological change.17 Here, TARDBP is linked to Alzheimer disease.