After all, investigations applying similar methods indicate that structural MRI can capture differential associations of the basal forebrain subnuclei with molecular markers of cholinergic neurotransmission.6,44 Furthermore, the differential association of the Ch4p area but not the whole basal forebrain with the ‘cholinergic deficit’ in the present data is corroborated by the observation that total basal forebrain volume does not differ between patients with pure AD pathology and patients with TDP-43 pathology in post mortem evaluations.17 Here, TARDBP is linked to Alzheimer disease.