In addition, the Fc domain of 23ME-01473 is afucosylated, which increases its binding affinity to the fragment crystallizable gamma receptor IIIa (FcγRIIIa), another activating receptor on NK cells, to augment the induction of antibody-dependent cellular cytotoxicity (ADCC) of ULBP6/2/5-expressing tumor cells and serve as a second activating signal for NK cells. Here, FCGR3A is linked to neoplasm.