Nonetheless, the lack of conservation of human ULBP6 and MICA/B in mice and the species differences in FcγR expression and affinities to hIgG1 limit our ability to evaluate the role of ULBP6 and 23ME-01473-mediated NKG2D and FcγRIIIa activation on tumor growth in the MC38 model. This evidence concerns the gene KLRK1 and neoplasm.