RAE1 and neoplasm: Despite these changes in the immune cells, the overexpression of human ULBP6 did not affect tumor growth in the MC38 model, potentially attributable to the model’s nondependency on human ULBP6 for its growth (Supplementary Fig. S5C) or redundancy of ULBP6 with the expression of endogenous murine NKG2DLs such as Rae-1 (51).