Evaluation of Kir2.1 expression in endothelial cells of TgF344-AD rats aged 3 to 14 months showed early elevation of Aβ, impaired hyperemic responses, and reduced Kir2.1 expression observed at 6 months suggesting a potential role of Kir2.1 dysfunction in cerebrovascular alterations linked to AD progression [99]. The gene discussed is KCNJ2; the disease is Alzheimer disease.