TET2 and lymphoma: For example, the R550* nonsense mutation is the most frequent TET2 somatic mutation reported in myeloid malignancy (47/3035) [40] and is also reported in lymphoma [12], astrocytoma [46], colorectal adenocarcinoma [47], endometrioid clear cell carcinoma [43], and squamous cell carcinoma of the upper aerodigestive tract [12] (Table 1).