Mechanistically, previous studies have shown that RIG‐I knockout disrupts gut microbiota by inhibiting IgA and IL6‐STAT3‐dependent Reg3γ expression [36], while others have reported that RIG‐I regulates biomarkers like polybromo‐1 [38] and insulin‐like growth factor‐1 receptor [39] in CRC. This evidence concerns the gene IL6 and colorectal carcinoma.