These enigmas, such as how a prototypical viral transforming agent is seminal to differentiation of leukemia cells - essentially a reversal of transformation, or how FGR causes genes controlled by RAREs to be expressed without any RA, are not as recondite if considered from the perspective of this novel paradigm for RA-induced differentiation for which the HL-60 model was the prototype. This evidence concerns the gene FGR and leukemia.