Stratification analyses for microalbuminuria, macroalbuminuria and end-stage renal disease (ESRD) were also conducted for five variants: Ins/Del variant at ACE gene; SNP rs2268388 at ACACB gene; SNP rs1799987 at CCR5 gene; SNPs rs1800795 and rs1800796 at IL-6 gene. The gene discussed is ACE; the disease is chronic kidney disease.