TCF7L2 and diabetic kidney disease: None of these highly credible associations reached genome-wide significance (P < 5 × 10-8) in the latest GWASs for DR and DKD [17,18], but nine credible associations were nominally significant (P < 0.05) in the GWASs, and rs55853916 at TCF7L2 gene is in high linkage disequilibrium with rs7903146, which has been reported as a genome-wide significant hit (P < 5 × 10-8) for DKD [82].