EXO5 and cancer: In this study, we focused on EXO5, a single-stranded DNA exonucleaseinvolved in DNA repair and previously associated with cancer susceptibility.11,66 Through an integrated approach that combines large-scale genomicdata analysis, protein language models, and MD simulations, we investigatedthe impact of common human EXO5 gene haplotypes onthe structural and dynamic properties of the EXO5 protein.