Notably, the EXO5 scorevariability of 7.8 was situated at the upper tail of this distribution,second only to RAD51B, which showed a maximum variability of 8.5.Additionally, an analysis of cancer somatic mutational profiles fromthe TCGA data set (via cBioPortal) revealed that among the genes withhaplotype variability greater than 2, several genes, including EXO5, RAD51B, NUDT15, SWSAP1, POLM, and CLK2- are recurrently altered in at least 2% of patients across variouscancer types, based on data from approximately 11,000 TCGA patients. Here, POLM is linked to cancer.