Given the heightened activation of immune cells in severe asthma, the differing trends in IL-36γ and IL-36Ra between sputum and blood may be attributed to varying activity in the originating cells and asthma severity, indicating that the specificity of IL-36 cytokines for airway or systemic inflammation could depend on their isoforms and on disease severity. The gene discussed is IL36RN; the disease is asthma.