The present study demonstrated several associations of serum IL-36 cytokines with asthma severity and clinical manifestations, including increased serum IL-36α, IL-36γ, and IL-36Ra levels in patients with asthma, especially severe asthma; the positive correlation of serum IL-36Ra with some pulmonary functions in asthma patients; and the relationship of serum IL-36 cytokines with each other and with serum T2 and non-T2 cytokines among the asthma patients. The gene discussed is IL36G; the disease is asthma.