Consistent with our findings, a previous study has reported that the mRNA expression and protein of these IL-36 cytokines were upregulated in the nasal tissues of eosinophil-dominant chronic rhinosinusitis,28 that peripheral blood eosinophils were activated by IL-36γ in allergic rhinitis patients,23 and that T2 airway inflammation and cytokine production was reduced by IL-36Ra and IL-38 in causative allergen-exposed mice,17,18,27 suggesting that the IL-36 cascade promotes allergic airway inflammation. This evidence concerns the gene IL36RN and allergic rhinitis.