In the present study, asthma patients with high IL-36Ra and IL-38 levels showed a deteriorating asthma status and were prone to SAEs; additionally, IL-36Ra and IL-38 were positively correlated with the agonistic IL-36 cytokines IL-6, IL-13, IL-17, and IFN-γ. The gene discussed is IFNG; the disease is asthma.