IL36A and asthma: Additionally, serum IL-36α levels were significantly higher in severe asthma patients compared to nonsevere asthma patients and healthy controls (median [interquartile range], pg/mL: 18.3 [12.5-57.4], 12.5 [12.5-12.5], and 12.5 [12.5-12.5]; severe vs nonsevere, P = .001; and severe vs controls, P = .0009, respectively) (Fig 1, A).