Serum IL-36α, IL-36β, IL-36γ, IL-36Ra, and IL-38 were detected in 37.3%, 42.7%, 43.6%, 18.2%, and 35.5% of asthma patients and in 19.4%, 48.4%, 22.6%, 0, and 22.6% of healthy controls, respectively. This evidence concerns the gene IL36RN and asthma.