Considering the anti-inflammatory effect of IL-36Ra, IL-38, and IL36RN reported in several studies,17, 18, 19,27,39,40 these findings suggest that the level of systemic antagonistic IL-36 cytokines increases to counteract the effect of proinflammatory cytokines and the worsening asthma condition and to prevent the development of future complications. This evidence concerns the gene IL1F10 and asthma.