Our findings are consistent with the findings of several studies showing that asthma patients with systemically elevated IL-6 levels exhibited reduced pulmonary function, low ACT, and more frequent AEs, SAEs, and hospitalizations36,37 and that the increased expression of IL-17 in the bronchial mucosa was correlated with increased SAEs and decline in percentage predicted FEV1.38 The gene discussed is IL17A; the disease is asthma.