Although the hypopigmentation is caused by the missing melanocytes in the two cases, the current case study showed no degenerative melanocyte morphology in hypopigmented lesions, thereby indicating that different mechanisms might underlie the formation of hypopigmentation in DSH and the SASH1-related dyschromatosis (Kondo et al., 2008). The gene discussed is SASH1; the disease is Dyschromatosis universalis.