Recently, several studies (Zhou et al., 2013; Zhong et al., 2019; Wu et al., 2020; Liu et al., 2021; Cao et al., 2021; Yang et al., 2023) have documented a distinct group of dyschromatosis in an autosomal dominant inherence pattern caused by mutations of SAM (sterile alpha motif) and SH3 (Src homology domain 3) domain-containing protein 1 gene (SASH1). Here, SASH1 is linked to Dyschromatosis universalis.