This observational study revealed that hemadsorption using the Efferon CT sorbent led to rapid and significant clinically beneficial changes, including a reduction in the necessity for norepinephrine, an increase in the oxygenation index, prevention of the sepsis-associated AKI, a decrease in the development of MOD and immune system indicators, including the markers of innate immunity and adaptive immunity and their balance, NLR, as well as pro-inflammatory IL-6 and ferritin levels. The gene discussed is IL6; the disease is acute kidney injury.