Diabetes, characterized by persistent hyperglycemia (25), leads to increased expression of chemokines (e.g., C-C motif chemokine 2) and adhesion molecules (e.g., intercellular adhesion molecule 1), which promote leukocyte migration (e.g., monocytes, neutrophils, lymphocytes) to the kidneys (26), initiating inflammation. Here, ICAM1 is linked to diabetes mellitus.