Our findings, especially at higher INR levels, align with previous reports suggesting that aPL can interfere with phospholipid-dependent coagulation reactions, particularly in POCT platforms, leading to overestimation of INR values.6This interference, noted particularly in LA-positive APS patients with high anti-β2-glycoprotein I titers,6raises concerns about the reliability of POCT-INR for guiding VKA therapy in these patients, potentially increasing the risk of thromboembolic events. The gene discussed is FASLG; the disease is autoimmune polyendocrinopathy.