The association between TG and first VTE was previously examined in The Thrombophilia, Hypercoagulability and Environmental Risks in Venous Thromboembolism (THE-VTE) study, in which an elevated TG (>90th percentile) was only weakly associated with first VTE (OR 1.8 95% CI 1.2–2.7).5Interestingly, in the THE-VTE study, mean peak height values measured in control subjects were relatively high (∼325 nM thrombin) compared with those obtained in the MEGA study (mean peak height ∼35 nM thrombin at low TF and ∼200 nM thrombin at high TF). This evidence concerns the gene TF and thrombophilia.