Our experiments with ex vivo incubation of 3WJ-PI-103 in a low pH environment were an important step to demonstrate rapid drug release from 3WJ-PI-103 that leads to efficient suppression of molecular signaling in cancer cells, but ex vivo experiments cannot confirm internalization of 3WJ-PI-103 nanoparticles by FRα-FA-3WJ interaction and drug escape from lysosomes. Here, FOLR1 is linked to cancer.